Architecture of the Gβγ-prefusion SNARE complex reveals the molecular mechanism of inhibition of vesicle fusion
Anna R. Eitel, Montana M. Young, Jackson B. Cassada, Eric W. Bell, Jens Meiler, Heidi E. Hamm
The paper determines the structure of the Gβγ-prefusion SNARE complex using cryo-EM and proposes a model for how Gβγ inhibits synaptic vesicle fusion by blocking SNARE complex assembly.
bioRxiv · Mar 7, 2026 · PreprintBiophysics