Application of polygenic scores to a deeply phenotyped sample enriched for substance use disorders reveals extensive pleiotropy with psychiatric and medical traits
Emily E. Hartwell, Zeal Jinwala, Jackson Milone, Sarah Ramirez, Joel E. Gelernter, Henry R. Kranzler, Rachel L. Kember
The paper uses polygenic scores to analyze pleiotropy between psychiatric, medical, and substance use disorders in a deeply phenotyped sample, finding extensive genetic overlap with substance use phenotypes.
Neuropsychopharmacology · Jul 23, 2024Peer-reviewedGenetic & Genomic Medicine