Joel E. Gelernter

The stuff that dreams are made of: Genomics and biology of nightmares

This study identifies genetic risk loci for nightmare frequency and explores its genetic correlations with psychiatric traits.

Posttraumatic Stress Disorder Epigenome-Wide Association Studies in the Million Veteran Program

This paper conducts a large-scale epigenome-wide association study of PTSD in the Million Veteran Program, identifying 272 CpG sites associated with PTSD traits and replicating prior findings.

Genomic Architecture of Migraine: A Multi ancestry GWAS Meta analysis of 2.5 Million Participants

This study conducts a multi-ancestry GWAS meta-analysis of 2.5 million participants to identify genetic variants associated with migraine and link them to biological pathways and therapeutic targets.

The Genetics of Fibromyalgia and its Relationships to Psychiatric and Medical Traits

This study identifies genetic loci associated with fibromyalgia and finds strong genetic correlations with psychiatric and medical traits.

Extending Genome-Wide Association Studies to admixed cohorts with high degrees of relatedness

The paper introduces Tractor-Mix, a mixed model method for GWAS in admixed cohorts with high relatedness, improving ancestry-specific association detection and controlling false positives.

Genomic Variation Predicts Real-Time Δ⁹-tetrahydrocannabinol Response in Humans

This study links genomic variation to real-time Δ9-THC response in humans, showing associations between CYP3A4 expression and psychotomimetic effects.

Multi-ancestry genome-wide association study and meta-analysis of stimulant use disorder reveals biology and relationships to other psychiatric disorders

This paper conducts a multi-ancestry GWAS of stimulant use disorder, identifies 19 genome-wide significant loci, and finds genetic correlations with other psychiatric and substance use disorders.

Shared epigenetic regulation acting on neuroimmune pathways contributes to the comorbidity between generalized anxiety disorder and COVID-19

The paper identifies shared epigenetic and genetic loci between generalized anxiety disorder and COVID-19, implicating neuroimmune pathways in their comorbidity.

Basal forebrain volume is associated with cortical amyloid burden in cognitively unimpaired older adults at varying genetic risk for Alzheimers disease

This study finds that nucleus basalis of Meynert (Ch4) volume is inversely associated with cortical amyloid burden in cognitively unimpaired adults at varying genetic risk for Alzheimer's disease.

Combinatorial effects of gene dosage, polygenic background and environment on complex traits

The paper examines how gene dosage, polygenic background, and environment influence complex traits like height and BMI using large-scale data from multiple cohorts.

Multivariate, Multi-omic Analysis in 799,429 Individuals Identifies 134 Loci Associated with Somatoform Traits

Pathways from Polygenic Risk to Suicidality: Effects of Alcohol Use Disorder and Childhood Adversity

The paper examines how polygenic risk for suicide attempts interacts with alcohol use disorder and childhood adversity to influence suicide attempt risk.

Genomic insights into substance use and disinhibitory disorders

This study identifies 1,294 genomic regions and 961 effector genes associated with externalizing disorders, revealing neural mechanisms and polygenic predictors of variance in these conditions.

Phenome-wide analysis of genetically imputed neuroimaging phenotypes reveals associations with psychiatric traits in a multi-ancestry cohort

The paper uses genetically imputed brain imaging phenotypes to find associations with psychiatric traits in a multi-ancestry cohort.

Multi-ancestry epigenome wide association study of generalized anxiety disorder

This study identifies 49 CpG sites associated with generalized anxiety disorder across three ancestries but finds limited replication in an independent cohort.

Genetics of SSRI Antidepressant Use and Relationship to Psychiatric and Medical Traits

This study identifies 40 genome-wide significant loci for SSRI use and finds genetic correlations with psychiatric and medical traits, suggesting SSRI use is a proxy for MDD with distinct genetic architecture.

A semi-empirical Bayes approach for calibrating weak instrumental bias in sex-specific Mendelian randomization studies

This paper develops a semi-empirical Bayesian framework to calibrate weak instrumental bias in sex-specific Mendelian randomization studies, revealing significant sex differences in causal effects of sleep phenotypes on cardiovascular diseases.

Multi-ancestry Genome-wide Association Study of Inpatient Opioid Dosing Following Knee or Hip Arthroplasty

This study investigates genetic predictors of inpatient opioid exposure after knee or hip surgery using EHR and genotype data from 27,896 individuals across three ancestries, finding no genome-wide significant loci.

A contextual genomic perspective on physical activity and its relationship to health, well-being and illness

This study investigates the genetic basis of physical activity across different contexts and finds that leisure-time activity has distinct genetic influences and protective health effects.

Multi-ancestry genetic architecture of sleep duration and its relationship to other sleep and psychiatric phenotypes

This paper conducts a multi-ancestry GWAS of sleep duration, identifying 234 genome-wide significant loci and showing distinct genetic architecture from other sleep and psychiatric traits.

Robust inference and widespread genetic correlates from a large-scale genetic association study of human personality

This study identifies 1,257 genetic variants associated with human personality traits using large-scale GWAS and finds widespread genetic correlations with behaviors and life outcomes.

Alcohol use disorder and body mass index show genetic pleiotropy and shared neural associations

The paper investigates genetic and neural overlaps between alcohol use disorder and BMI, finding polygenic overlap despite minimal genetic correlation and identifying shared brain regions involved in executive function and reward.

The Landscape of Shared and Divergent Genetic Influences across 14 Psychiatric Disorders

The paper identifies five genomic factors explaining most genetic variance across 14 psychiatric disorders and finds shared and disorder-specific genetic signals with distinct biological functions.

Integrating HiTOP and RDoC Frameworks Part II: Shared and Distinct Biological Mechanisms of Externalizing and Internalizing Psychopathology

The paper integrates HiTOP and RDoC frameworks to identify shared and distinct biological mechanisms of externalizing and internalizing psychopathology using multi-omics approaches.

Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits.

This study performs a multi-ancestral GWAS of DSM-defined nicotine dependence, finding genetic correlations with other substance use disorders and health traits, and identifying a strong general addiction liability factor.

Integrating HiTOP and RDoC Frameworks Part I: Genetic Architecture of Externalizing and Internalizing Psychopathology

The paper uses genomic structural equation modeling to identify the genetic architecture of externalizing and internalizing psychopathology, finding a moderate genetic correlation and shared causal variants.

Opioid use disorder and brain health: observational andgenetic associations

This paper investigates the causal impact of opioid use disorder on brain health outcomes using observational and genetic analyses, finding increased dementia risk associated with both OUD diagnoses and genetic predisposition to OUD.

Genetics of posttraumatic stress disorder and cardiovascular conditions using Lifes Essential 8, Electronic Health Records, and Heart Imaging

This study identifies shared genetic loci and genes between PTSD and cardiovascular conditions using GWAS across multiple data sources and finds overlapping biological pathways and drug targets.

A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology.

This study conducts a genome-wide association analysis of the Big Five personality traits, identifying novel genetic loci and associations with psychiatric traits.

Application of polygenic scores to a deeply phenotyped sample enriched for substance use disorders reveals extensive pleiotropy with psychiatric and medical traits

The paper uses polygenic scores to analyze pleiotropy between psychiatric, medical, and substance use disorders in a deeply phenotyped sample, finding extensive genetic overlap with substance use phenotypes.