Single Particle Adsorption and Response Quantification for Functional AAVx Titer and Dose Analysis
Chiranth K. Nagaraj, Truc Kim Nugyen, Kwang Joo Kwak, Bilal Bayazit, Xin Huang, Jackson S. Newell, Jacob Doon‐Ralls, Xilal Y. Rima, Scott Q. Harper, Nizar Y. Saad, Eduardo Reátegui
This paper introduces SPARQ, a method to quantify functional AAV vectors at single-particle resolution, revealing functional heterogeneity and improving dose analysis in gene therapy.
bioRxiv · May 29, 2026 · PreprintBioengineering