Polytraumatic SCI worsens maladaptive plasticity in spinal motor systems
Jason H. Gumbel, Jacob A. Davis, Kerui Gong, Cleopa Omondi, Jeffrey A. Sacramento, Emma Iorio, Abel Torres Espin, Jenny Haefeli, Kazuhito Morioka, Adam R. Ferguson, John Russell Huie
This study investigates how polytraumatic spinal cord injury (SCI) combined with spared nerve injury (SNI) exacerbates maladaptive plasticity in spinal motor systems through increased GluA1 expression and AMPAR currents.
bioRxiv · Jun 30, 2026 · PreprintNeuroscience