Crystal Structure of Caryolan-1-ol Synthase, a Sesquiterpene Synthase Catalyzing an Initial Anti-Markovnikov Cyclization Reaction
Ramasamy Prem Kumar, Jason O. Matos, Brandon Y. Black, William H. Ellenburg, Jiahua Chen, MacKenzie Patterson, Jacob A. Gehtman, Douglas L. Theobald, Isaac J. Krauss, Daniel D. Oprian
The paper solves the crystal structure of caryolan-1-ol synthase with and without a substrate analog, revealing structural changes that suggest a mechanism for anti-Markovnikov cyclization.
Biochemistry · Oct 14, 2024Peer-reviewedBiochemistry