Ramasamy Prem Kumar

The paper identifies dual-action kinase inhibitors that block the active site and enhance p38α dephosphorylation by stabilizing an accessible activation loop conformation.

The paper solves the crystal structure of caryolan-1-ol synthase with and without a substrate analog, revealing structural changes that suggest a mechanism for anti-Markovnikov cyclization.

The paper identifies a coiled-coil linker mechanism in RsbU that activates the General Stress Response in bacteria by transducing signals from sensor domains.