BioPKS Pipeline: An integrated platform for merging the computational design of chimeric type I polyketide synthases with enzymatic pathways for chemical biosynthesis
Yash Chainani, Jacob Diaz, Margaret Guilarte-Silva, Vincent Blay, Quan Zhang, William Sprague, Keith E. J. Tyo, Linda J. Broadbelt, Aindrila Mukhopadhyay, Jay D. Keasling, Héctor García Martín, Tyler W. H. Backman
BioPKS Pipeline automates the design of chimeric type I polyketide synthases and enzymatic pathways to synthesize target chemicals, achieving exact designs for 93 of 155 tested molecules and proposing routes for complex natural products.
bioRxiv · Nov 4, 2024 · PreprintBioinformatics