Targeting pathogenic VWF/ADAMTS13 dysregulation attenuates CTEPH progression
Zhijian Wu, Huan Dong, Quan Zhang, Zhirong Chai, Anlun Li, Esteban Mauricio Dominguez, Xinyang Zhao, Leslie A. Spikes, Michael J. Soares, X. Long Zheng, Liang Zheng
This study identifies VWF/ADAMTS13 dysregulation as a driver of CTEPH progression and shows that targeting this axis reduces thrombosis and vascular remodeling in rat models.
bioRxiv · Jun 22, 2026 · PreprintPathology