Tyler W. H. Backman

This paper introduces a modular polyketide synthase platform for producing diols, amino alcohols, and hydroxyacids using engineered Streptomyces albus strains.

BioPKS Pipeline automates the design of chimeric type I polyketide synthases and enzymatic pathways to synthesize target chemicals, achieving exact designs for 93 of 155 tested molecules and proposing routes for complex natural products.

BayFlux quantifies metabolic fluxes and their uncertainty using Bayesian inference, showing genome-scale models reduce flux uncertainty compared to core models and improve knockout predictions.

The paper presents tools for storing, visualizing, and leveraging multiomics data to predict outcomes of bioengineering efforts.