Collagen IV of basement membrane: V. Bromide-mediated sulfilimine bonds interlock the quaternary structure of NC1-hexamer of scaffolds enabling metazoan evolution.
Bradley P. Clarke, Vadim K. Pedchenko, Tetyana V. Pedchenko, Monica Moran, Jacob Edwards, Kyle T Vallone, Carl E Darris, Gautam B. Bhave, Patrick Page-McCaw, Julie K. Hudson, Sergei P. Boudko, Billy G. Hudson
The paper shows that sulfilimine bonds stabilize the quaternary structure of Col-IV121 hexamers across species and that bromide-mediated bond formation is evolutionarily conserved.
Journal of Biological Chemistry · Mar 6, 2026Peer-reviewedMolecular Biology