Brainstem development requires galactosylceramidase and is critical for the pathogenesis of Krabbe Disease
Nadav I. Weinstock, Conlan Kreher, Jacob Favret, Duc At Nguyen, Ernesto Roque Bongarzone, Lawrence G. Wrabetz, M. Laura Feltri, Daesung Shin
This study shows that GALC is critical for brainstem development and KD pathogenesis, with a specific vulnerability period between postnatal days 4-6.
Nature Communications · Oct 23, 2020Peer-reviewedNeuroscience