Lawrence G. Wrabetz

This study shows that deleting Sarm1 reduces axonal degeneration in a CMT2J mouse model, but does not fully prevent disease progression.

This study shows that loss of Phb2 in Schwann cells disrupts myelination and dysregulates key transcription factors essential for peripheral nerve development.

This study shows that p38γMAPK inhibits oligodendrocyte differentiation and myelin repair, and is enriched in multiple sclerosis lesions.

The paper develops a P0T124M mouse model of CMT2J neuropathy, showing axonal damage without significant myelin defects and altered axo-glia communication.

This study shows that mTORC1 and JUN are activated in Schwann cells lacking Prohibitin 1, contributing to demyelination through mitochondrial dysfunction.

This study shows that GALC is critical for brainstem development and KD pathogenesis, with a specific vulnerability period between postnatal days 4-6.

This study shows that increasing neuregulin 1 type III in neurons improves myelination in a mouse model of congenital hypomyelinating neuropathy without relying on Egr2 or typical myelin genes.

This study shows that enhancing Nrg1TIII signaling reduces disease severity in a CMT1B mouse model by rebalancing myelin lipids and proteins, not through myelin gene upregulation.