Author

Jacob Kimberg

The University of Texas Southwestern Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Alexander-Hoi Nguyen· 1 shared Anthony J. DavisiD· 1 shared David G. McFaddeniD· 1 shared Juan Manuel PovedanoiD· 1 shared Vicky LiiD· 1 shared Wei‐Min CheniD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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1 shared paperCancer Biology

Alexander-Hoi Nguyen

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1 paper

Recent·Most cited

Cancer BiologyACS Chemical BiologyPeer-reviewedSep 11, 2026

Ultramutagenesis through combined Msh2 depletion and proofreading-deficient DNA polymerase ε expression enhances small molecule target identification in forward genetic screens

Alexander-Hoi Nguyen, Vicky Li, Wei‐Min Chen…·Juan Manuel Povedano

This study combines Msh2 depletion and proofreading-deficient DNA polymerase ε expression to enhance mutagenesis, enabling identification of drug resistance mutations and cytotoxin mechanisms in SCLC cells.

DOI 10.1021/acschembio.6c00605

mousewhole-exome sequencing

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