David G. McFadden

This study combines Msh2 depletion and proofreading-deficient DNA polymerase ε expression to enhance mutagenesis, enabling identification of drug resistance mutations and cytotoxin mechanisms in SCLC cells.

The paper identifies germline mutations in complex I subunits as a driver of Warburg metabolism in oncocytic thyroid carcinoma through loss of heterozygosity.

This study creates inducible EWSR1-FLI1 degron alleles in tumor cell lines to control fusion oncoprotein expression, showing reversible cell cycle arrest and tumor growth suppression in xenografts.