A Library of Custom PEG-Lipids reveals a Double-PEG-Lipid with Drastically Enhanced Paclitaxel Solubility and Human Cancer Cell Cytotoxicity when used in Fluid Micellar Nanoparticles
Aria Ghasemizadeh, Lili Wan, Aiko Hirose, Jacqueline Diep, Kai K. Ewert, Cyrus R. Safinya
This paper develops a library of PEG-lipids to enhance paclitaxel solubility and cytotoxicity in fluid micellar nanoparticles, finding that double-PEG-lipid 2k2 significantly improves solubility and efficacy.
bioRxiv · Aug 1, 2024 · PreprintBioengineering