Cyrus R. Safinya

Multivalent Lipid MVL5 Micellar Nanoparticles Exhibit Dramatically Increased Loading of Paclitaxel with PEGylation Enhancing Human Cancer Cell Penetration Depth and Cytotoxicity

This study shows that MVL5-based micellar nanoparticles enhance paclitaxel solubility and cytotoxicity in cancer cells, with PEGylation improving cellular uptake and penetration.

Acidic Conditions Promote Clustering of Cancer Cell Derived Extracellular Vesicles and Enhance their Fusion with Synthetic Liposomes

This paper demonstrates that acidic conditions enhance EV-liposome fusion without additional fusogens, supported by FRET and microscopy, and suggests implications for drug delivery.

Mixtures of Intrinsically Disordered Neuronal Protein Tau and Anionic Liposomes Reveal Distinct Anionic Liposome-Tau Complexes Coexisting with Tau Liquid-Liquid Phase Separated Coacervates

This paper investigates the interactions between tau protein and anionic liposomes, revealing distinct complexes and phase-separated coacervates under varying ionic conditions.

A Library of Custom PEG-Lipids reveals a Double-PEG-Lipid with Drastically Enhanced Paclitaxel Solubility and Human Cancer Cell Cytotoxicity when used in Fluid Micellar Nanoparticles

This paper develops a library of PEG-lipids to enhance paclitaxel solubility and cytotoxicity in fluid micellar nanoparticles, finding that double-PEG-lipid 2k2 significantly improves solubility and efficacy.