Exhaustive Isotope Tracing Reveals the Butterfly Effect of Mammalian Producer Cell Line Selection for Biomanufacturing
Venkata Gayatri Dhara, Jacqueline E. Gonzalez, Harnish Mukesh Naik, Brian O. McConnell, Pratik Anay Khare, Justin Sargunas, Maciek R. Antoniewicz, Michael J. Betenbaugh
This study uses isotope tracing to compare metabolic differences between two CHO cell lines, revealing how cell line selection impacts metabolism and biomanufacturing.
bioRxiv · Aug 5, 2026 · PreprintCell Biology