Integrative Analysis of Drug-Gene Expression Signatures in Human Pluripotent Stem Cells Identifies Novel Drug Candidates for ALS and Monogenic Diseases
Florine Roussange, Jacqueline Gide, Johana Tournois, Michel Cailleret, Anne Boland, Christophe Battail, Jean‐François Deleuze, Hélène Polvèche, Didier Auboeuf, Knut Brockmann, Edor Kabashi, Anca Marian, Lina El Kassar, Sophie Blondel, François Salachas, , Sandrine Baghdoyan
The paper identifies novel drug candidates for ALS and monogenic diseases by analyzing drug-induced gene expression changes in human pluripotent stem cells using RNA sequencing.
bioRxiv · Feb 4, 2025 · PreprintGenomics