Hélène Polvèche

The SF3B1 inhibitor pladienolide B massively inhibits DNA damage signaling and repair and counteracts resistance to platinum salts in Non-Small Cell Lung Cancer

This paper shows that the SF3B1 inhibitor pladienolide B inhibits DNA damage repair and counteracts platinum resistance in NSCLC by inducing genomic instability and altering DNA repair gene splicing.

The AMPK-related kinase NUAK1 regulates neuronal morphogenesis through the RNA splicing co-factor SON

This study identifies NUAK1 as a regulator of alternative splicing in cortical neurons through phosphorylation of SON, linking it to neurodevelopmental processes and ZTTK syndrome.

DAB2 as a biomarker and mechanistic link between lipid dysregulation and disease progression in LGMD R2

Integrative Analysis of Drug-Gene Expression Signatures in Human Pluripotent Stem Cells Identifies Novel Drug Candidates for ALS and Monogenic Diseases

The paper identifies novel drug candidates for ALS and monogenic diseases by analyzing drug-induced gene expression changes in human pluripotent stem cells using RNA sequencing.

Alternative splicing of SORBS1 affects neuromuscular junction formation and stability in myotonic dystrophy type 1

This study shows that abnormal splicing of SORBS1 exon 25 in DM1 contributes to neuromuscular junction formation and stability issues in skeletal muscle.

Helicases DDX5 and DDX17 promote Hepatitis B Virus transcription termination heterogeneity in infected human hepatocytes

The paper identifies DDX5 and DDX17 as factors promoting HBV transcriptional readthrough and affecting viral RNA stability and replication.

SplicingLore: a web resource for studying the regulation of cassette exons by human splicing factors

SplicingLore provides a database of alternative exons regulated by 75 splicing factors, enabling analysis of splicing factor interactions and exon regulation.

Myogenesis modelled by human pluripotent stem cells uncovers Duchenne muscular dystrophy phenotypes prior to skeletal muscle commitment

This study uses hiPSCs from DMD patients to model myogenesis and identifies early disease phenotypes before skeletal muscle commitment.

Intragenic recruitment of NF-κB drives alternative splicing modifications upon activation by the viral oncogene TAX of HTLV-1.

The paper shows that NF-κB recruitment to gene bodies via TAX activates alternative splicing through DDX17, affecting oncogenic pathways in HTLV-1 infection.

Physical and functional interaction between SET1/COMPASS complex component CFP-1 and a Sin3 HDAC complex

The paper identifies a physical and functional interaction between CFP-1 and the Sin3 HDAC complex in C. elegans, showing their coordinated regulation of gene expression.

Interplay between coding and exonic splicing regulatory sequences

The paper shows that exons regulated by the same splicing factor share similar nucleotide composition and code for amino acids with similar physicochemical properties.

Interplay between gene nucleotide composition bias and splicing

The paper identifies GC-rich and AT-rich exons with distinct splicing factor dependencies and shows how nucleotide composition bias influences chromatin organization and exon recognition during splicing.