Didier Auboeuf

The SF3B1 inhibitor pladienolide B massively inhibits DNA damage signaling and repair and counteracts resistance to platinum salts in Non-Small Cell Lung Cancer

This paper shows that the SF3B1 inhibitor pladienolide B inhibits DNA damage repair and counteracts platinum resistance in NSCLC by inducing genomic instability and altering DNA repair gene splicing.

Integrative Analysis of Drug-Gene Expression Signatures in Human Pluripotent Stem Cells Identifies Novel Drug Candidates for ALS and Monogenic Diseases

The paper identifies novel drug candidates for ALS and monogenic diseases by analyzing drug-induced gene expression changes in human pluripotent stem cells using RNA sequencing.

Translation-dependent and independent mRNA decay occur through mutually exclusive pathways that are defined by ribosome density during T Cell activation.

The paper shows that mRNA decay during T cell activation occurs through translation-dependent and independent pathways, with ribosome density determining the pathway used.

The MYCN oncoprotein and helicases DDX17 and DDX5 have opposite effects on the production of chimeric transcripts in neuroblastoma cells

This study shows that MYCN and helicases DDX17/DDX5 have opposing roles in transcription termination and chimeric transcript production in neuroblastoma, with MYCN inhibiting helicase activity and promoting harmful RNA molecules.

Gene-to-Gene Coordinated Regulation of Transcription and Alternative splicing by 3D Chromatin Remodeling upon NF-κB activation

This study investigates how NF-κB activation through HTLV-1 Tax reorganizes 3D chromatin to coordinate transcription and alternative splicing of target genes.

Intronic polyadenylation isoforms in the 5' part of genes constitute a source of microproteins and are involved in cell response to cisplatin

The paper identifies microproteins encoded by intronic polyadenylation isoforms in the 5' part of genes and shows their role in modulating cisplatin response in cancer cells.

MET functions in tumour progression and therapy resistance are repressed by intronic polyadenylation

The paper shows that intronic polyadenylation (IPA) of MET affects tumour progression and therapy resistance by producing a short MET isoform that reduces invasiveness and enhances response to MAPK-targeted therapy.

SplicingLore: a web resource for studying the regulation of cassette exons by human splicing factors

SplicingLore provides a database of alternative exons regulated by 75 splicing factors, enabling analysis of splicing factor interactions and exon regulation.

Intragenic recruitment of NF-κB drives alternative splicing modifications upon activation by the viral oncogene TAX of HTLV-1.

The paper shows that NF-κB recruitment to gene bodies via TAX activates alternative splicing through DDX17, affecting oncogenic pathways in HTLV-1 infection.

Interplay between coding and exonic splicing regulatory sequences

The paper shows that exons regulated by the same splicing factor share similar nucleotide composition and code for amino acids with similar physicochemical properties.

Interplay between gene nucleotide composition bias and splicing

The paper identifies GC-rich and AT-rich exons with distinct splicing factor dependencies and shows how nucleotide composition bias influences chromatin organization and exon recognition during splicing.