Sodium channel endocytosis drives axon initial segment plasticity
Amélie Freal, Nora Jamann, Jolijn ten Bos, Jacqueline Jansen, Naomi Petersen, Thijmen W. Ligthart, Casper C. Hoogenraad, Maarten H. P. Kole
The paper shows that NMDA receptor-mediated long-term synaptic depression causes rapid endocytosis of sodium channels from the distal AIS, revealing a mechanism for activity-dependent AIS reorganization.
Science Advances · Sep 15, 2023Peer-reviewedNeuroscience