Author

Thijmen W. Ligthart

Amsterdam University Medical CentersORCID 0000-0002-7573-0177Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Neuroscience· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:differential expression· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Amélie FrealiD· 1 shared Casper C. HoogenraadiD· 1 shared Débora Pita-IllobreiD· 1 shared Fleur Schipper· 1 shared Jacqueline Jansen· 1 shared Jasper Franciscus Maria SmitsiD· 1 shared Jolijn ten BosiD· 1 shared Ka Wan LiiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperNeuroscience

Amélie FrealORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

GVB-positive neurons are resilient to tau-induced impairment of protein synthesis

Jasper Franciscus Maria Smits, Thijmen W. Ligthart, Marta Jorge‐Oliva, Skip Middelhoff, Fleur Schipper, Débora Pita-Illobre, Ka Wan Li, Wiep Scheper

The paper shows that GVB-positive neurons are protected against tau-induced protein synthesis impairment and neurodegeneration.

bioRxiv · Mar 28, 2025 · PreprintNeuroscience

Sodium channel endocytosis drives axon initial segment plasticity

Amélie Freal, Nora Jamann, Jolijn ten Bos, Jacqueline Jansen, Naomi Petersen, Thijmen W. Ligthart, Casper C. Hoogenraad, Maarten H. P. Kole

The paper shows that NMDA receptor-mediated long-term synaptic depression causes rapid endocytosis of sodium channels from the distal AIS, revealing a mechanism for activity-dependent AIS reorganization.

Science Advances · Sep 15, 2023Peer-reviewedNeuroscience