Maarten H. P. Kole

The nanoscopic submyelin space mediates efficient K+ uptake and shapes nodal action potentials

The paper develops a finite element model to study K+ dynamics and action potential behavior at the node of Ranvier, revealing how periaxonal K+ buffering enables high-frequency conduction.

Divisive normalization in mouse V1 is unchanged by increased thalamocortical short-term depression

This study investigates whether short-term depression at thalamocortical synapses contributes to divisive normalization in mouse V1, finding no effect on contrast response or cross-orientation suppression.

Spatiotemporal proteomics elucidates trafficking and localization of Neuroligins to the axon initial segment plasma membrane

The paper uses spatiotemporal proteomics to study the trafficking and localization of NLGN1 and NLGN2 to the axon initial segment, revealing distinct sorting mechanisms and functional roles.

An organotypic neocortical slice culture for studying neuroglial interactions

This study develops an organotypic neocortical slice culture to study neuroglial interactions across development and disease states.

Robust activity-dependent mitochondrial calcium dynamics at the AIS is dispensable for action potential generation

The paper investigates the role of mitochondrial calcium dynamics at the axon initial segment (AIS) in action potential generation and finds they are dispensable for this function.

Tether-mediated extraction of myelinoid bodies by microglia and astrocytes can maintain myelin integrity

The paper shows that microglia and astrocytes extract myelinoid bodies via tethers, preserving myelin sheath integrity through tension-driven scission and fusion.

Spatially resolved mapping of monoacylglycerol lipase activity in the brain

The paper introduces fluorescent activity-based probes to map MAGL activity in brain tissues, revealing its spatial distribution in mouse and human brains.

Experience Shapes Chandelier Cell Function and Structure in the Visual Cortex

This study shows that chandelier cells in the visual cortex change their function and structure with experience, responding more to arousal-related events and showing plasticity in their connections.

Human voltage-gated Na+ and K+ channel properties underlie sustained fast AP signaling

The paper shows that biophysical properties of Na+ and K+ channels in human pyramidal neurons enable fast and reliable input-output signaling.

Sodium channel endocytosis drives axon initial segment plasticity

The paper shows that NMDA receptor-mediated long-term synaptic depression causes rapid endocytosis of sodium channels from the distal AIS, revealing a mechanism for activity-dependent AIS reorganization.

Parvalbumin basket cell myelination accumulates axonal mitochondria to internodes

The paper investigates mitochondrial clustering in myelinated segments of PV+ basket cell axons and shows that demyelination affects mitochondrial distribution while noncompacted myelin preserves clustering.

Myelin speeds cortical oscillations by consolidating phasic parvalbumin-mediated inhibition

This study shows that myelination of parvalbumin-positive interneurons is essential for fast inhibition and modulation of cortical oscillations during specific behavioral states.

Complement-associated loss of CA2 inhibitory synapses in the demyelinated hippocampus impairs memory

The paper investigates complement system involvement in synapse loss in MS hippocampus, finding C1q deposits linked to inhibitory synapse loss and impaired memory.

Sensory input drives rapid homeostatic scaling of the axon initial segment in mouse barrel cortex

The paper shows sensory input drives rapid homeostatic scaling of the axon initial segment in mouse barrel cortex, with sensory deprivation increasing AIS length and excitability, while enrichment shortens AIS and reduces action potential generation.

A role of oligodendrocytes in information processing independent of conduction velocity

This study shows that oligodendrocytes contribute to sustained stimulus perception in complex auditory tasks, beyond their role in increasing axonal conduction velocity.

HCN channel-mediated neuromodulation can control action potential velocity and fidelity in central axons

This study shows HCN channels modulate action potential velocity and fidelity in central axons through cAMP and neuromodulators, with implications for energy consumption and temporal delays.