Lupus auto-antibodies act as positive allosteric modulators at NMDA receptors and induce spatial memory deficits
Kelvin Chan, Jacquelyn Nestor, Tomas S. Huerta, Noele Certain, Gabrielle R. Moody, Czeslawa Kowal, Patricio T. Huerta, Bruce T. Volpe, Betty Diamond, Lonnie P. Wollmuth
The paper shows that lupus auto-antibodies modulate NMDA receptors and cause spatial memory deficits, with GluN2A subunits being more sensitive to these antibodies.
bioRxiv · Oct 3, 2019 · PreprintNeuroscience