Betty Diamond

This study defines the single-cell landscape of Class II lupus nephritis and identifies fibroblast transcriptional programs and chronicity index as potential predictors of kidney outcomes.

The paper identifies spatially distinct macrophage-fibroblast interactions in lupus nephritis that drive myofibroblast heterogeneity and fibrosis.

The paper uses serum proteomics to identify molecular signatures that classify lupus nephritis, differentiate disease activity and chronicity, and predict treatment response.

This study uses single-cell RNA-sequencing and spatial transcriptomics to analyze myeloid cell dynamics in lupus nephritis, showing shifts in immune responses linked to disease progression.

The paper identifies distinct genetic mechanisms for early (nuclear) and late (cellular) RNA eQTL by comparing their genomic localization and functional effects across tissues.

This study compares B-cell subsets in active SLE, remission, and healthy controls to identify immunological differences and potential therapeutic targets.

The paper shows that BBB-disrupting factors induce BMVECs to release EVs with distinct protein profiles that alter transcriptional programs and may serve as markers of BBB disruption.

The paper examines four new anti-Caspr2 antibodies, showing they target different epitopes and induce varying ASD-like phenotypes in male mice offspring.

A single-cell atlas of blood and tissue samples from lupus nephritis patients and healthy controls identifies stromal and immune populations, including scar-associated macrophages, which correlate with disease activity.

The paper identifies a subgroup of SLE patients with high plasmablast frequency and IFN signature, enriched in those with Sm/RNP antibodies, linking IFN to B cell hyperactivity and autoantibody production.

The paper shows LAIR1 expression decreases during B cell differentiation and is regulated by the IL-21/STAT3 pathway, with implications for B cell autoreactivity and systemic lupus erythematosus.

This study analyzes B cell receptor sequences in SLE patients to understand autoreactive B cell selection and differentiation, finding that ABCs are enriched in autoreactivity and may arise from naive B cells through an extrafollicular pathway.

The paper shows that ultrasound neuromodulation of the spleen reduces experimental pulmonary hypertension by improving hemodynamics and reducing inflammation.

The paper identifies epigenetic differences in B cells from treatment-naive pediatric lupus patients compared to healthy children, showing distinct chromatin accessibility patterns and potential regulatory roles in disease.

The paper shows that lupus auto-antibodies modulate NMDA receptors and cause spatial memory deficits, with GluN2A subunits being more sensitive to these antibodies.

This paper establishes a protocol for preserving and analyzing single-cell transcriptomes from cryopreserved renal tissue and urine samples in lupus nephritis studies.