Patricio T. Huerta

This study shows age-dependent cholinergic deficits in the dorsal motor nucleus of the vagus in experimental Alzheimer's disease, leading to impaired vagus nerve function.

This study shows that in utero exposure to anti-Caspr2 antibodies reduces PV+ interneurons and disrupts inhibitory circuitry in the hippocampus, linking it to ASD-related behavioral impairments.

The paper examines four new anti-Caspr2 antibodies, showing they target different epitopes and induce varying ASD-like phenotypes in male mice offspring.

This study identifies vasoactive neuropeptide dysregulation as a key driver of microvascular dysfunction and cognitive decline in chronic cerebral hypoperfusion.

This study shows that butyrate supplementation prevents cognitive impairments and blood-brain barrier damage in mice with gut microbiome depletion caused by antibiotics.

This study compares the efficacy of single-chain variable fragments (scFvs) targeting different tau epitopes in reducing cerebral tau in transgenic mice, finding that scFv-MC1 monotherapy is more effective than combination therapy.

This study shows that both acute and chronic diving reflex activate NRF2 signaling, with acute exposure inducing stronger antioxidative gene expression than chronic exposure.

This study investigates how social context and dominance hierarchy influence decision-making during spatial navigation in mice, revealing the role of prefrontal cortex and hippocampus activity.

The paper shows that lupus auto-antibodies modulate NMDA receptors and cause spatial memory deficits, with GluN2A subunits being more sensitive to these antibodies.