Spacer sequences separating transcription factor binding motifs set enhancer quality and strength
Marion Guéroult-Bellone, Kazuhiro R. Nitta, Willi Kari, Edwin H. Jacox, Rémy Beulé Dauzat, Renaud Vincentelli, Carine Diarra, Ute Rothbächer, Christelle Dantec, Christian Cambillau, Jacques Piette, Patrick Lemaire
The paper shows that spacer sequences between transcription factor binding motifs influence enhancer activity and that randomizing these spacers can awaken dormant genomic clusters of TFBM.
bioRxiv · Jan 6, 2017 · PreprintDevelopmental Biology