Renaud Vincentelli

The paper reports a large-scale quantitative interactome of human PDZ domains and bacterial PDZ-binding motifs, showing bacteria tailor effector sequences to bind with similar or higher affinity than human PBMs to hijack host functions.

This study characterizes recombinant disintegrins from Echis species, showing distinct inhibitory effects on platelet aggregation and endothelial cell migration.

The paper maps over 20,000 human protein-protein interactions mediated by short linear motifs using a peptide library screening approach.

The paper investigates the role of RomRX and MglB in regulating cell polarity in Myxococcus xanthus, showing RomRX acts as an effector of MglAGTP and competes with MglB to modulate complex stability.

The paper develops a method to produce and activate purified snake venom metalloproteinases (SVMPs) using recombinant zymogens, enabling detailed biochemical and functional analysis.

The paper screens polysaccharide utilization loci (PULs) targeting marine polysaccharides, identifies novel enzymes, and characterizes their functions and synergies.

This paper develops a high-throughput screening pipeline to identify carbohydrate-binding modules (CBMs) that bind synthetic and natural polymers, discovering binders for PET, PE, PS, and polysaccharides, and demonstrating their utility in enhancing plastic-degrading enzyme activity.

The paper introduces a high-throughput mass-spectrometry-based assay to measure protein-ligand affinity constants, demonstrating its application to 14-3-3 isoforms and phosphopeptides.

The paper describes the development of PDZome 2.0, a Yeast Two-Hybrid resource for PDZ domain interactions, showing improved performance over the previous version using HPV16 E6 as a bait.

The paper measures affinities of 65,000 PDZ domain interactions using quantitative fragmentomics, revealing viral interference hotspots and system-wide impacts of interactome hijacking.

The paper investigates how phosphorylation of a PDZ-binding linear motif alters interactions with PDZ domains, showing widespread modulation of binding affinities rather than discrete on/off switches.

The paper shows that spacer sequences between transcription factor binding motifs influence enhancer activity and that randomizing these spacers can awaken dormant genomic clusters of TFBM.