Hyperactive GluN2B impairs neuroplasticity and cognition in phenylketonuria
Woo Seok Song, Young Sook Kim, Young-Soo Bae, Sang Ho Yoon, Jae Min Lim, Myoung‐Hwan Kim
This study shows that elevated phenylalanine levels in PKU hyperactivate GluN2B-containing NMDARs, impairing synaptic plasticity and cognition, and suggests GluN2B suppression as a potential therapy.
Journal of Clinical Investigation · May 8, 2025Peer-reviewedNeuroscience