MOPD I patient-derived cerebral organoids model microcephaly showing premature neurogenesis due to disrupted mitotic spindle orientation.
Jagjit Singh, Noah J. Daniels, Filomena Pirozzi, Anthony J. Wynshaw-Boris, Rodrigo Lopez-Gonzalez, Richard A. Padgett
This study uses patient-derived cerebral organoids to show that MOPD I mutations cause disrupted mitotic spindle orientation, leading to premature neurogenesis and cortical layering defects.
bioRxiv · Dec 29, 2022 · PreprintNeuroscience