Anthony J. Wynshaw-Boris

This study uses microglia-containing human cerebral assembloids to analyze neuroimmune interactions during homeostasis and HIV infection, revealing microglial reactivity and neuroprotective responses.

The paper identifies PBX1 as a convergent target of autism risk genes that influences neural progenitor cell proliferation in ASD.

This study develops a 3D tissue platform with collagen and stem cells to screen cell-cell and cell-matrix interactions, showing enhanced vascularization and identifying pathways affecting vasculogenesis and ASD models.

The paper uses lineage tracing in human cortical organoids to show that most neurons arise from intermediate progenitors and that genetic variants affect lineage-specific transcriptional profiles and neuron diversity.

The paper shows that a PTEN p.I135L mutation and an ASD genetic background together disrupt cortical neurogenesis in iPSC-derived NPCs and organoids.

This study uses patient-derived cerebral organoids to show that MOPD I mutations cause disrupted mitotic spindle orientation, leading to premature neurogenesis and cortical layering defects.

The paper shows LIS1 regulates cleavage plane positioning by controlling actomyosin-mediated cell membrane contractility in neural progenitor cells.