Activity-dependent capture reveals brain-wide signatures of isoflurane anesthesia-induced unconsciousness
Minke H.C. Nota, Lukas K. MacMillen, Hallie Lazaro, Jaidyn O. Gaur, Ian Campuzano, Carlie Neiswanger, Sam A. Golden, Mitra Heshmati
The paper identifies brain-wide neural circuits activated by isoflurane anesthesia and shows chemogenetic manipulation of these circuits reproduces key aspects of unconsciousness.
bioRxiv · May 29, 2026 · PreprintNeuroscience