Defective DcpS Decapping Manifests in Creatine Deficiency Syndrome and Neurological impairment
Jun Yang, Geeta Palsule, Xinfu Jiao, Jaime S Messenger, Ronald P. Hart, Megerditch Kiledjian
This study identifies creatine deficiency as the underlying cause of neurogenesis defects in DcpS mutant cells and shows creatine supplementation reverses the phenotype.
Scientific Reports · May 23, 2025Peer-reviewedCell Biology