Megerditch Kiledjian

This study identifies glyco-modified RNAs in exosomes, showing their role in intercellular communication and suggesting a link between protein and RNA glycosylation.

This study identifies creatine deficiency as the underlying cause of neurogenesis defects in DcpS mutant cells and shows creatine supplementation reverses the phenotype.

The paper identifies deFADding activity in 5' to 3' exoribonucleases, showing they can degrade FAD-capped RNAs in yeast, human, and bacterial systems.

The paper identifies Xrn1 as a deNADding enzyme in yeast that modulates mitochondrial NAD levels by releasing NAD from NAD-capped RNAs.

This study shows that DcpS, an mRNA-decapping enzyme, is critical for neuronal development and that its mutation leads to developmental delay and intellectual disability.

This study identifies Nudt12 as a new deNADding enzyme distinct from DXO, showing it targets NAD-capped RNAs and links these RNAs to cellular metabolism.