Inhibition of the Notch signaling pathway promotes AQP2 plasma membrane accumulation in renal epithelial cells by depolymerizing actin and reducing endocytosis
Asma Tchakal-Mesbahi, Huihui Huang, Jake Charles Ross, Richard Bouley, Dennis Brown
This study shows that inhibiting Notch signaling increases AQP2 membrane accumulation in renal epithelial cells by reducing endocytosis and disrupting actin polymerization.
bioRxiv · Aug 12, 2026 · PreprintCell Biology