Author

Dennis Brown

Harvard UniversityORCID 0000-0002-5011-7798Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Organism:mouse· 1

Frequent Co-Authors

Asma Tchakal-MesbahiiD· 2 shared Richard BouleyiD· 2 shared Amity F. EatoniD· 1 shared Elizabeth C. DanielsoniD· 1 shared Hua A. Jenny LuiD· 1 shared Huihui HuangiD· 1 shared Jake Charles Ross· 1 shared Jinzhao HeiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

Asma Tchakal-MesbahiORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cell BiologybioRxivPreprintAug 12, 2026

Inhibition of the Notch signaling pathway promotes AQP2 plasma membrane accumulation in renal epithelial cells by depolymerizing actin and reducing endocytosis

Asma Tchakal-Mesbahi, Huihui Huang, Jake Charles Ross…·Dennis Brown

This study shows that inhibiting Notch signaling increases AQP2 membrane accumulation in renal epithelial cells by reducing endocytosis and disrupting actin polymerization.

DOI 10.64898/2026.08.11.744289

proteomicsexperimental assay

𝕏 PostBluesky

Cell BiologyAmerican Journal of Physiology-Renal PhysiologyPeer-reviewedAug 26, 2025

Focal Adhesion Kinase (FAK) inhibition induces membrane accumulation of aquaporin2 (AQP2) through endocytosis inhibition and actin depolymerization in renal epithelial cells.

Asma Tchakal-Mesbahi, Jinzhao He, Shuai Zhu…·Hua A. Jenny Lu

This study shows FAK inhibition leads to AQP2 membrane accumulation by blocking endocytosis and causing actin depolymerization in renal cells.

3 citations

proteomicsexperimental assay

𝕏 PostBluesky

PhysiologyAmerican Journal of Physiology-Renal PhysiologyPeer-reviewedMay 13, 2025

Knockout of the V-ATPase interacting protein Tldc2 in B-type kidney intercalated cells impairs urine alkalinization

Amity F. Eaton, Elizabeth C. Danielson, Leona J. Tu…·Maria Merkulova

This study shows that Tldc2 knockout in B-type kidney intercalated cells impairs urine alkalinization and bicarbonate secretion, suggesting Tldc2's role in renal acid-base regulation.

5 citations

mousebulk RNA-seq

𝕏 PostBluesky