PALB2 maintains redox and mitochondrial homeostasis in the brain and cooperates with ATG7 to suppress p53 dependent neurodegeneration
Yanying Huo, Akshada Sawant, Yongmei Tan, Amar Mahdi, Tao Li, Hui Ma, Vrushank Dharmesh Bhatt, Run Yan, Jake Coleman, Cheryl F. Dreyfus, Jessie Yanxiang Guo, M. Maral Mouradian, Eileen White, Bing Xia
This study shows that PALB2 maintains redox and mitochondrial homeostasis in the brain and works with ATG7 to prevent p53-dependent neurodegeneration.
bioRxiv · Jun 7, 2021 · PreprintNeuroscience