Author

Yongmei Tan

Peking University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:protein structure prediction· 2 Assay:structural biology· 2 Organism:mouse· 1

Frequent Co-Authors

Akshada SawantiD· 1 shared Amar MahdiiD· 1 shared Bing XiaiD· 1 shared Chengpeng FaniD· 1 shared Cheryl F. DreyfusiD· 1 shared Eileen WhiteiD· 1 shared Hailin PengiD· 1 shared Hui MaiD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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1 shared paperNeuroscience

Akshada SawantORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Structural Mechanism of TRPC3 Channel Activation by the Moonwalker Mutation

Jiahe Zang, Yongmei Tan, Yikun Chen, Wenjun Guo, Xiaole Zhao, Hailin Peng, Lie Chen

The paper presents structures of hTRPC3 in resting and open states, revealing how the moonwalker mutation activates the channel by disrupting a polar interaction and inducing structural changes.

Cell Discovery · Oct 29, 2026Peer-reviewedBiophysics

Inhibition mechanism of pancreatic KATP channels by centipede toxins

Tianyi Hou, Mengmeng Wang, Yongmei Tan, Chengpeng Fan, Lei Chen

This paper identifies centipede toxins SpTx1 and Sm3a as inhibitors of human pancreatic KATP channels, revealing their binding mechanism and therapeutic potential for neonatal diabetes.

Research · Jan 1, 2026Peer-reviewedBiophysics

PALB2 maintains redox and mitochondrial homeostasis in the brain and cooperates with ATG7 to suppress p53 dependent neurodegeneration

Yanying Huo, Akshada Sawant, Yongmei Tan, Amar Mahdi, Tao Li, Hui Ma, Vrushank Dharmesh Bhatt, Run Yan, Jake Coleman, Cheryl F. Dreyfus, Jessie Yanxiang Guo, M. Maral Mouradian, Eileen White, Bing Xia

This study shows that PALB2 maintains redox and mitochondrial homeostasis in the brain and works with ATG7 to prevent p53-dependent neurodegeneration.

bioRxiv · Jun 7, 2021 · PreprintNeuroscience