Loss of Ag85A disrupts plasma membrane domains and promotes free mycolic acid accumulation in mycobacteria.
Takehiro Kado, Shivangi, Jake Jordan, Joel S. Freundlich, M. Sloan Siegrist, Yasu S. Morita
This study shows that Ag85A is essential for plasma membrane domain organization in mycobacteria, leading to mycolic acid accumulation and altered cell envelope structure.
bioRxiv · Aug 5, 2025 · PreprintMicrobiology