Joel S. Freundlich

This paper presents a method to quantify intrabacterial drug accumulation and metabolism in Gram-negative bacteria using liquid chromatography-mass spectrometry, showing correlations with drug efficacy and synergy.

This study shows that Ag85A is essential for plasma membrane domain organization in mycobacteria, leading to mycolic acid accumulation and altered cell envelope structure.

This paper shows that the mycomembrane of Mycobacterium tuberculosis and M. smegmatis differentially and heterogeneously restricts antibiotic permeation using the PAC-MAN method.

The paper identifies chemical features affecting mycomembrane permeation and antitubercular activity using a bioorthogonal assay and machine learning.

The paper develops a hybrid modeling pipeline to identify antitubercular compounds with favorable potency and pharmacokinetics, resulting in 12 promising candidates from a large compound library.

This paper identifies CymR-derived pentapeptides as nanomolar inhibitors of SaCysK, showing higher potency than CysE-derived peptides.