A JAK-STAT-activated myeloid hub at ulceration sites underlies resistance to anti-TNF therapy in Crohn's disease
Thomas Laurent, Monika Mykhaylyshyn, Jake Thomas, Gaëlle Bériou, Lucas Otero-Laudouar, Lucas Brusselle, Aurélie Joussaume, Cécile Braudeau, Justine Chevreuil, Cynthia Fourgeux, Laurence Bouchet‐Delbos, Martin Braud, Nicolas Chapelle, Mathieu Uzzan, Pablo Canales-Herrerías, , J. P. D. Martin
The paper identifies a JAK-STAT-activated myeloid subset, IFIM, associated with anti-TNF resistance in Crohn's disease and proposes JAK inhibition as a therapeutic strategy.
bioRxiv · Feb 13, 2026 · PreprintImmunology