CLONAL LYMPHOCYTE EXPANSIONS AND JAK-STAT PATHWAY MUTATIONS DEFINE A PATHOGENIC CONTINUUM DRIVING RESISTANCE TO GLUTEN-FREE DIET IN CELIAC DISEASE
Georgia Malamut, Nicolas Guégan, Francesco Carbone, Antoine de Giacomoni, Adélaïde Ferment, Cécile Masson, Marine Luka, Sascha Cording, Christine Bôle‐Feysot, Mathurin Fuméry, Tamara Matysiak‐Budnik, Guillaume Bouguen, Véred Abitbol, Romain Coriat, Benoît Terris, , Anaïs Levescot
This study identifies clonal lymphocyte expansions and JAK-STAT mutations in celiac disease subtypes, revealing shared mechanisms and limitations of JAK inhibitor therapy.
Gastroenterology · Apr 17, 2026Peer-reviewedCancer Biology