Author

Lucas Brusselle

Inserm

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Jérémie PoschmanniD· 2 shared Andreas SchlitzeriD· 1 shared Ángela Sanzo-MachucaiD· 1 shared Arnaud BourreilleiD· 1 shared Aurélie JoussaumeiD· 1 shared Axel You· 1 shared Azucena SalasiD· 1 shared Catherine Le BerreiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersImmunology

Jérémie PoschmannORCID

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2 papers

Recent·Most cited

Cross-species chromatin accessibility pinpoints HIVEP3 as a driver of thymic epithelial maturation and self-antigen expression, preventing chronic inflammation

Sümeyye Yayilkan, Marie Massoda, Séverine Ménoret, Axel You, Lucas Brusselle, Claire Usal, Laurent Tesson, Mathieu Rouel, Flore Couzy, Francine Padonou, Cloé Zamit, Jérémy C. Santamaria, Pierre Maminirina, Olivier Baron, Jérôme Jullien, , Matthieu Giraud

This study identifies HIVEP3 as a critical regulator of thymic epithelial maturation and self-antigen expression, with its deficiency causing chronic inflammation.

bioRxiv · Jun 19, 2026 · PreprintImmunology

A JAK-STAT-activated myeloid hub at ulceration sites underlies resistance to anti-TNF therapy in Crohn's disease

Thomas Laurent, Monika Mykhaylyshyn, Jake Thomas, Gaëlle Bériou, Lucas Otero-Laudouar, Lucas Brusselle, Aurélie Joussaume, Cécile Braudeau, Justine Chevreuil, Cynthia Fourgeux, Laurence Bouchet‐Delbos, Martin Braud, Nicolas Chapelle, Mathieu Uzzan, Pablo Canales-Herrerías, , J. P. D. Martin

The paper identifies a JAK-STAT-activated myeloid subset, IFIM, associated with anti-TNF resistance in Crohn's disease and proposes JAK inhibition as a therapeutic strategy.

bioRxiv · Feb 13, 2026 · PreprintImmunology