Cynthia Fourgeux

The PGC-1α Gly482Ser rs8192678 SNP reprograms oxidative metabolism to favor energy storage in females

This study shows that the PGC-1α Gly482Ser SNP reprograms oxidative metabolism to favor energy storage, especially in females, through reduced respiratory capacity and altered metabolic responses.

A JAK-STAT-activated myeloid hub at ulceration sites underlies resistance to anti-TNF therapy in Crohn's disease

The paper identifies a JAK-STAT-activated myeloid subset, IFIM, associated with anti-TNF resistance in Crohn's disease and proposes JAK inhibition as a therapeutic strategy.

TDG orchestrates ATF4-dependent gene transcription during retinoic acid-induced cell fate acquisition

The paper investigates TDG's role in cell differentiation by showing its involvement in ATF4-dependent gene transcription during retinoic acid-induced neural fate commitment.

Inference and validation of a dynamic gene regulatory network influencing cell fate during Duchenne muscular dystrophy initiation

The paper identifies a dynamic gene regulatory network in Duchenne muscular dystrophy that controls cell fate decisions and shows how disease mutations disrupt this network.

Sperm derived H2AK119ub1 is required for embryonic development in Xenopus Laevis

The paper shows that sperm-derived H2AK119ub1 is essential for embryonic development in Xenopus laevis by guiding epigenetic remodelling of paternal chromatin.

The immune profile of circulating autoreactive CD4 T cells is imprinted through tissue activation during autoimmune liver diseases

This study identifies the transcriptional profile of circulating autoreactive CD4 T cells in autoimmune liver diseases and shows their functional relationship to liver-specific pathogenic clones.

SCellBOW: AI-Driven Tumor Risk Stratification from Single-Cell Transcriptomics Using Phenotype Algebra

SCellBOW identifies and risk-stratifies tumor cell subpopulations using scRNA-seq data by simulating their impact on disease prognosis.