STING and VDAC inhibitors attenuate inflammation and ineffective erythropoiesis caused by an altered metabolome in the Nan (EKLF/E339D) mouse model of neonatal anemia
Tasleem Arif, Kaustav Mukherjee, Xue Li, Jonathan Leon Catrow, James Cox, James J. Bieker
The paper shows that STING and VDAC inhibitors reduce inflammation and ineffective erythropoiesis in a Nan mouse model by targeting metabolic dysregulation and cGAS-STING pathway activation.
bioRxiv · Dec 12, 2025 · PreprintMolecular Biology