Jonathan Leon Catrow

This study shows that mitochondrial cardiolipin deficiency disrupts electron transport chain function, leading to oxidative stress and promoting MASH in mice and humans.

The paper describes a reversible form of suspended animation in C. elegans induced by high population density and identifies molecular mechanisms regulating its induction and termination.

The paper shows that STING and VDAC inhibitors reduce inflammation and ineffective erythropoiesis in a Nan mouse model by targeting metabolic dysregulation and cGAS-STING pathway activation.

This study shows that heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue by affecting UCP1 and mitochondrial function.