Cytochrome P450 26b1-mediated specification of vestibular striola and central zones is required for transient responses in linear acceleration
Kazuya Ono, James Keller, Omar López, Antonia González-Garrido, Omid A. Zobeiri, Vanessa Rong Jen Chang, Sarath Vijayakumar, Andrianna I. Ayiotis, Gregg Duester, Charles C. Della Santina, Sherri M. Jones, Kathleen E. Cullen, Ruth Anne Eatock, Doris K. Wu
This study shows that Cyp26b1-mediated RA degradation during embryogenesis is essential for patterning vestibular zones, which are critical for transient responses to linear acceleration.
bioRxiv · Aug 6, 2019 · PreprintNeuroscience