Author

Sarath Vijayakumar

Creighton UniversityORCID 0000-0002-4652-2002Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:mouse· 4 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:zebrafish· 2 Approach:experimental assay· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Jian ZuoiD· 2 shared Marisa ZallocchiiD· 2 shared Shu Tu· 2 shared Yuju Li· 2 shared Abdul-Rizaq Ali HamoudiD· 1 shared Ali Sajid ImamiiD· 1 shared Andrianna I. AyiotisiD· 1 shared Antonia González-GarridoiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersNeuroscience

Jian ZuoORCID

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4 papers

Recent·Most cited

Hair Bundle Degeneration is a Key Contributor to Age-Related Vestibular Dysfunction

Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia R. Bloom, Shu Tu, Benjamin J. Borgmeier, Mi Ζhou, Litao Tao, Bechara Kachar, David Z. Z. He

The paper identifies age-related molecular and cellular changes in vestibular hair cells that contribute to vestibular dysfunction by impairing mechanotransduction and hair bundle integrity.

bioRxiv · Feb 2, 2025 · PreprintNeuroscience

In Silico Transcriptome-based Screens Identify Epidermal Growth Factor Receptor Inhibitors as Therapeutics for Noise-induced Hearing Loss

Sarath Vijayakumar, Joseph DiGuiseppi, Parinaz J. Dabestani, William G. Ryan, René Vielman Quevedo, Yuju Li, Jack Diers, Shu Tu, Jonathan P. Fleegel, Cassidy Nguyen, Lauren M. Rhoda, Ali Sajid Imami, Abdul-Rizaq Ali Hamoud, Sándor Lovas, Robert Erne McCullumsmith, , Jian Zuo

This paper identifies EGFR inhibitors as potential therapeutics for noise-induced hearing loss using in silico transcriptome-based drug screening and experimental validation in zebrafish and mouse models.

Science Advances · Jun 19, 2024Peer-reviewedNeuroscience

In silico transcriptomics identifies FDA-approved drugs and biological pathways for protection against cisplatin-induced hearing loss

Pezhman Salehi, Marisa Zallocchi, Sarath Vijayakumar, Madeleine E. Urbanek, Kimberlee P. Giffen, Yuju Li, Santanu Hati, Jian Zuo

The paper uses in silico transcriptomics to identify FDA-approved drugs and pathways that protect against cisplatin-induced hearing loss, validating niclosamide as a potential otoprotectant.

bioRxiv · Jan 26, 2022 · PreprintNeuroscience

Cytochrome P450 26b1-mediated specification of vestibular striola and central zones is required for transient responses in linear acceleration

Kazuya Ono, James Keller, Omar López, Antonia González-Garrido, Omid A. Zobeiri, Vanessa Rong Jen Chang, Sarath Vijayakumar, Andrianna I. Ayiotis, Gregg Duester, Charles C. Della Santina, Sherri M. Jones, Kathleen E. Cullen, Ruth Anne Eatock, Doris K. Wu

This study shows that Cyp26b1-mediated RA degradation during embryogenesis is essential for patterning vestibular zones, which are critical for transient responses to linear acceleration.

bioRxiv · Aug 6, 2019 · PreprintNeuroscience