SIRT3 deficiency decreases oxidative-metabolism capacity but increases lifespan under caloric restriction
Rashpal S. Dhillon, Yiming Qin, Paul R. van Ginkel, Vivian X. Fu, James M. Vann, Alexis J. Lawton, Cara L. Green, Fúlvia de Barros Manchado-Gobatto, Cláudio Alexandre Gobatto, Dudley W. Lamming, Tomas A. Prolla, John M. Denu
This study shows that SIRT3 deficiency under caloric restriction increases lifespan but decreases aerobic capacity and mitochondrial function.
bioRxiv · May 9, 2022 · PreprintMolecular Biology